• Five cases of Wilson's disease were diagnosed in a family of eight siblings. All of them had Kayser-Fleischer rings. The first neurologic symptoms appeared in one person at age 46 years; in another, psychotic symptoms appeared at age 38 years; and in one patient, jaundice was noted at age 40 years. Two other persons, aged 53 and 43 years, were still without hepatic, neurologic, or psychiatric symptoms of the disease at the time of writing. The family described is very atypical with regard to the age at onset of Wilson's disease.
Czlonkowska A, Rodo M. Late Onset of Wilson's Disease: Report of a Family. Arch Neurol. 1981;38(11):729–730. doi:10.1001/archneur.1981.00510110089019
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