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December 1981

Adult-Onset Nemaline Rods in a Patient Treated for Suspected Dermatomyositis: Study With Two-Dimensionaln Electrophoresis

Author Affiliations

From the Departments of Neurology (Drs Danon and Perurena), Pathology (Drs Danon and Manaligod), and Medicine (Dr Skosey), University of Illinois Medical Center, Chicago; and the Molecular Anatomy Program, Argonne (Ill) National Laboratory (Dr Giometti).

Arch Neurol. 1981;38(12):761-766. doi:10.1001/archneur.1981.00510120061010

• A 65-year-old woman with progressive muscle weakness and a diffuse rash of three years' duration was examined. Muscle tissue was studied with histochemical techniques, phase-contrast microscopy, electron microscopy, and twodimensional electrophoresis. Histochemical studies showed numerous nemaline rods, with a normal ratio of types I and II fibers. Two-dimensional electrophoresis revealed abnormalities in the myosin light chain and tropomyosin protein patterns when compared with normal and diseased muscle biopsy samples, including those from two patients with adult-onset dermatomyositis.

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