• A 65-year-old woman with progressive muscle weakness and a diffuse rash of three years' duration was examined. Muscle tissue was studied with histochemical techniques, phase-contrast microscopy, electron microscopy, and twodimensional electrophoresis. Histochemical studies showed numerous nemaline rods, with a normal ratio of types I and II fibers. Two-dimensional electrophoresis revealed abnormalities in the myosin light chain and tropomyosin protein patterns when compared with normal and diseased muscle biopsy samples, including those from two patients with adult-onset dermatomyositis.
Danon MJ, Giometti CS, Manaligod JR, Perurena OH, Skosey JL. Adult-Onset Nemaline Rods in a Patient Treated for Suspected Dermatomyositis: Study With Two-Dimensionaln Electrophoresis. Arch Neurol. 1981;38(12):761–766. doi:10.1001/archneur.1981.00510120061010
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.