Spontaneous Remission of Infantile Spasms With Hypsarhythmia

To the Editor.—  Infantile spasms in the first year of life, with hypsarhythmia on EEG, are associated with a high incidence of retardation.¹ A few such patients ultimately have normal intelligence and are free of seizures. The literature suggests that the likelihood of a good prognosis is enhanced by the early institution of therapy with corticotropin,^2-5 particularly in the cryptogenic cases.The case presented here represents classic infantile spasms associated with hypsarhythmia. No medication was used, and a spontaneous remission occurred.

Report of a Case.—  A 7-month-old boy was first seen in consultation for frequent bursts of typical flexor spasms that had appeared when the patient was 2 months of age, associated with slowing of development. Family history, pregnancy, labor, delivery, patient's history, and patient's development before this were normal. He had had no immunizations. At 5 months of age, while still having the infantile spasms, an