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February 1982

Effect of Naloxone on the 'On-Off' Syndrome in Patients Receiving Long-term Levodopa Therapy

Author Affiliations

From the Departments of Pharmacology (Dr Trabucchi) and Neurology (Drs Bassi and Frattola), University of Milan (Italy).

Arch Neurol. 1982;39(2):120-121. doi:10.1001/archneur.1982.00510140054014

• Naloxone hydrochloride, an opiate antagonist, was given to six parkinsonian patients suffering from the "on-off" phenomenon. Although the drug does not modify the cardinal symptoms of parkinsonism, it reduces dyskinetic movements and the length of the rigid phase. There may be an interaction of opiate receptors with the different neurotransmitter systems involved in the on-off syndrome.

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