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March 1982

Inclusion Body Myositis Associated With Sjögren's Syndrome

Author Affiliations

From the Departments of Neurology (Drs Chad, Adelman, and Bradley and Mr Good) and Pathology (Dr Adelman), Tufts New England Medical Center, and the Department of Medicine, Harvard Medical School, Massachusetts General Hospital (Dr Mills), Boston.

Arch Neurol. 1982;39(3):186-188. doi:10.1001/archneur.1982.00510150056014

• A patient with polymyositis had the pathological hallmarks of inclusion body myositis (IBM) as well as features that to our knowledge have never before been reported in IBM—an associated collagenvascular disease (Sjögren's syndrome) and tubuloreticular structures in capillary endothelial cells. The pathogenesis of IBM is unknown, but its coexistence with Sjögren's syndrome suggests that immune mechanisms may play a role in producing muscle damage.