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Article
May 1982

HLA Frequencies in Amyotrophic Lateral Sclerosis

Arch Neurol. 1982;39(5):270-271. doi:10.1001/archneur.1982.00510170012003
Abstract

• Our study of the distribution of HLA-A, -B, and -C in patients with amyotrophic lateral sclerosis (ALS) found no statistically significant deviation. We found a trend, however, toward a decrease in HLA-A9, as we had reported previously, and toward an increase in HLA-Bw35 and -Cw4. The worldwide incidence of ALS is uniform except in Guam and on Japan's Kii peninsula, and published reports from many countries, including Guam, show no consistent deviation in HLA frequencies related to ALS.

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