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May 1982

HLA Frequencies in Amyotrophic Lateral Sclerosis

Author Affiliations

From the Amyotrophic Lateral Sclerosis Research Center, St Vincent's Hospital and Medical Center of New York (Drs Bartfeld and Donnenfeld) and the Tissue Typing Laboratory (Dr Pollack) and Clinical Immunology Laboratory (Dr Cunningham-Rundles), Memorial Sloan-Kettering Cancer Center, New York.

Arch Neurol. 1982;39(5):270-271. doi:10.1001/archneur.1982.00510170012003

• Our study of the distribution of HLA-A, -B, and -C in patients with amyotrophic lateral sclerosis (ALS) found no statistically significant deviation. We found a trend, however, toward a decrease in HLA-A9, as we had reported previously, and toward an increase in HLA-Bw35 and -Cw4. The worldwide incidence of ALS is uniform except in Guam and on Japan's Kii peninsula, and published reports from many countries, including Guam, show no consistent deviation in HLA frequencies related to ALS.