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May 1982

Bone Marrow Studies in Patients With Multiple Sclerosis

Author Affiliations

From the Division of Clinical Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, Japan (Drs Ohara, Takase, and Itahara); and the Department of Bacteriology, Yamagata (Japan) University School of Medicine (Drs Tashiro and Homma).

Arch Neurol. 1982;39(5):317. doi:10.1001/archneur.1982.00510170059020

Mitchell et al1 examined bone marrow aspirates from five patients with recent exacerbations of multiple sclerosis (MS). They found increased numbers of reticulum cells, including primitive forms, occasional large atypical phagocytic cells, and plasma cells. They also reported the detection of a transmissible cytopathic agent, either by cocultivation of the bone marrow cells with HEp-2, Vero, or MRC-5 (diploid cell line) cells or by inoculating them into the same cells after treatment with lysolecithin.

We carried out morphological and virological examinations of the bone marrow of patients with MS and optic neuritis (ON) in an effort to confirm these findings.

METHODS  Bone marrow specimens were obtained from 11 patients (six women and five men) with MS and one woman with ON. The diagnosis of MS was based on the criteria proposed in 1972 by the Multiple Sclerosis Research Committee of Japan, Ministry of Health and Welfare.2 The mean

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