Mitchell et al1 examined bone marrow aspirates from five patients with recent exacerbations of multiple sclerosis (MS). They found increased numbers of reticulum cells, including primitive forms, occasional large atypical phagocytic cells, and plasma cells. They also reported the detection of a transmissible cytopathic agent, either by cocultivation of the bone marrow cells with HEp-2, Vero, or MRC-5 (diploid cell line) cells or by inoculating them into the same cells after treatment with lysolecithin.
We carried out morphological and virological examinations of the bone marrow of patients with MS and optic neuritis (ON) in an effort to confirm these findings.
Bone marrow specimens were obtained from 11 patients (six women and five men) with MS and one woman with ON. The diagnosis of MS was based on the criteria proposed in 1972 by the Multiple Sclerosis Research Committee of Japan, Ministry of Health and Welfare.2 The mean
Ohara Y, Takase S, Itahara K, Tashiro M, Homma M. Bone Marrow Studies in Patients With Multiple Sclerosis. Arch Neurol. 1982;39(5):317. doi:10.1001/archneur.1982.00510170059020
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