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May 1982

Oligoclonal Bands in Myoclonus Epilepsy-Reply

Author Affiliations

Department of Neurology University of Helsinki Helsinki, Finland
Department of Virology University of Tampere Tampere, Finland
University of Helsinki
Infectious Diseases Branch Bldg 36, Room 5D-06 National Institutes of Health Bethesda, MD 20205

Arch Neurol. 1982;39(5):321. doi:10.1001/archneur.1982.00510170063024

In Reply.—  We appreciate Dr Keshgegian's comments. Following the publication of our report on immunologic abnormalities in the CSF of patients with progressive myoclonus epilepsy, we developed a micromethod for detection of oligoclonal IgG in unconcentrated CSF by polyacrylamide gel electrophoresis.1 We tested for oligoclonal IgG bands in the same samples (a small amount of CSF was available from each of the 16 patients with progressive myoclonus epilepsy) using our micromethod. A positive finding was detected in 12 of 16 patients. The indirect immunofixation technique, including surface fixation with specific antiserum2 and peroxidase-tagged antiglobulin with diaminobenzidine,3 demonstrated that these bands were immunoglobulins of the γ-G class.