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July 1982

Meige's Syndrome During Long-term Dopaminergic Therapy in Parkinson's Disease

Author Affiliations

From the Department of Neurological Sciences, Rush-Presbyterian-St Lukes Medical Center, Chicago.

Arch Neurol. 1982;39(7):451-452. doi:10.1001/archneur.1982.00510190069027

The blepharospasm-oromandibular dystonia syndrome was first described by Meige in 1910.1 He described patients afflicted with preponderantly symmetric dystonic spasms of the facial muscles who also might have dystonic movements involving other midline muscle groups. After the original description of this bizarre and oftentimes disabling movement disorder, little was mentioned in the medical literature until 1972, when reports of isolated oromandibular dystonia2 and oromandibular dystonia with blepharospasm appeared.3

Since that time there has been increasing attention paid to this syndrome, including a suggestion that it be termed Brueghel's syndrome, after the Dutch painter who created portraits that captured the distinctive dystonic facial postures seen in this syndrome.4 Marsden has described the largest series of these patients and has noted that the syndrome is adult onset (usually in the sixth decade), with the initial symptom being either blepharospasm or oromandibular dystonia alone or, most frequently, a combination

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