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August 1982

Oculomotor Effects of Intermittent Conduction Block in Myasthenia Gravis and Guillain-Barré Syndrome: An Oculographic Study With Computer Simulations

Author Affiliations

From the Neuro-ophthalmology Unit, Departments of Neurology, Neurological Surgery, and Ophthalmology, School of Medicine, University of California, San Francisco; and the Departments of Ophthalmology and Neurosurgery, School of Medicine, University of Southern California, Los Angeles (Dr Feldon).

Arch Neurol. 1982;39(8):497-503. doi:10.1001/archneur.1982.00510200039007

• Five abnormal oculographic patterns were identified in eight patients with either myasthenia gravis or Guillain-Barré syndrome (GBS). These could be differentiated into three intrasaccadic and two postsaccadic abnormalities. From our studies of computer simulations, and considering the established pathophysiology of myasthenia gravis and GBS, we believe that our oculographic findings were a consequence of defects in peripheral neural and neuromuscular conduction, together with a simple adaptive increase in duration of the saccadic burst of central innervation. We conclude that the eye movement abnormalities we observed are explained by intermittent block of peripheral conduction, and suggest that any disease causing intermittent blockage of neural signals to extraocular muscles will produce similar abnormalities of eye movement.

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