• Five abnormal oculographic patterns were identified in eight patients with either myasthenia gravis or Guillain-Barré syndrome (GBS). These could be differentiated into three intrasaccadic and two postsaccadic abnormalities. From our studies of computer simulations, and considering the established pathophysiology of myasthenia gravis and GBS, we believe that our oculographic findings were a consequence of defects in peripheral neural and neuromuscular conduction, together with a simple adaptive increase in duration of the saccadic burst of central innervation. We conclude that the eye movement abnormalities we observed are explained by intermittent block of peripheral conduction, and suggest that any disease causing intermittent blockage of neural signals to extraocular muscles will produce similar abnormalities of eye movement.
Feldon SE, Stark L, Lehman SL, Hoyt WF. Oculomotor Effects of Intermittent Conduction Block in Myasthenia Gravis and Guillain-Barré Syndrome: An Oculographic Study With Computer Simulations. Arch Neurol. 1982;39(8):497–503. doi:10.1001/archneur.1982.00510200039007
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: