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August 1982

Metrizamide Myelography Combined With Computed Tomography in Adrenomyeloneuropathy

Author Affiliations

Department of Neurology
Department of Radiology University Hospital of Antwerp Antwerp, Belgium
Department of Neurology St Elisabeth Hospital Herentals, Belgium

Arch Neurol. 1982;39(8):530. doi:10.1001/archneur.1982.00510200072018

To the Editor.—  Metrizamide myelography combined with computed tomographic (CT) exploration of the spine can demonstrate the presence of a thin, possibly atrophic, spinal cord and rule out compression as the cause of spastic paraparesis noted in adrenomyeloneuropathy (AMN). We describe a man with AMN who was a member of an afflicted family to stress the diagnostic support provided by this combined radiologic procedure.

Report of a Case.—  A 21-year-old man complained of increasing paraparesis and sphincter disturbances. A pyramidal syndrome involved all four limbs with Babinski's signs. There was impaired proprioception in both legs and decreased exteroceptive sensations below thoracic level 10 on the right side and lumbar L-2 on the left side. Mental functions were normal. Premature incomplete baldness and a very thin beard were noted. There were no clinical signs of adrenal insufficiency. A brother and a first cousin of the patient suffered from adrenoleukodystrophy, while his