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Article
August 1982

Multiple Sclerosis and Hypokalemic Periodic Paralysis in the Same Patient

Author Affiliations

Department of Neurology Temple University Hospital 3401 N Broad St Philadelphia, PA 19140

Arch Neurol. 1982;39(8):530-531. doi:10.1001/archneur.1982.00510200072019

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Abstract

To the Editor.—  We have observed a case of multiple sclerosis (MS) and periodic paralysis occurring in the same patient.

Report of a Case.—  A 26-year-old man had had attacks of generalized weakness lasting several hours on awakening since the age of 10 years. These attacks would occur infrequently and always after meals rich in carbohydrates.At the age of 21 years, he was hospitalized at another institution during a severe attack. At admission, the serum potassium level was 2.8 mEq/L; results of thyroid function tests were normal. His serum potassium level was corrected, and the weakness disappeared. A muscle biopsy specimen showed minimal changes. Other members of his family had had similar attacks. A diagnosis of familial periodic paralysis was made. The patient was given diuretics with potassium supplementation, and the attacks stopped.We saw this patient at the age of 24 years because of an unsteady gait, numbness

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