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September 1982

Transient Polyradiculoneuropathy Following a Febrile Transfusion Reaction

Author Affiliations

From the Departments of Medicine (Drs Ritch and Hansen) and Neurology (Dr McQuillen), Medical College of Wisconsin and Milwaukee County Medical Complex, Milwaukee.

Arch Neurol. 1982;39(9):597-598. doi:10.1001/archneur.1982.00510210067020

We recently observed a case of short-lived polyradiculoneuropathy in a patient with acute leukemia in whom the apparent antecedent event was a severe hyperpyrexic transfusion reaction.

REPORT OF A CASE  A 69-year-old woman previously in good health was seen by her physician in April 1981 because of a mild upper respiratory tract illness and left upper-quadrant discomfort; she was found to have a leukocytosis with undifferentiated cells circulating in the peripheral blood. The spleen was enlarged but there was no peripheral lymphadenopathy. The WBC count was 88,000/cu mm, the majority of which were undifferentiated blast cells. Bone marrow examination showed increased cellularity, and the predominant cell type was an undifferentiated blast form. Cytochemical staining was inconclusive and the cells were terminal deoxynucleotidyl transferase positive. Subsequent cytogenetic analysis showed a normal karyotype.Treatment was initiated with daunorubicin hydrochloride, cytarabine, vincristine sulfate, and prednisone, and there was prompt clearing of immature

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