• The angular gyrus syndrome (posterior aphasia, alexia with agraphia, and Gerstmann's syndrome) shares many clinical features with Alzheimer's disease, and the two conditions are easily confused. Preservation of memory and topographical orientation and the specific typology of the language defects help to distinguish the angular gyrus syndrome. X-ray computed tomograms may prove misleading, but isotope metabolic studies demonstrated left posterior cortical hypometabolism in two cases.