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October 1982

Angular Gyrus Syndrome Simulating Alzheimer's Disease

Author Affiliations

From the Neurobehavioral Service, UCLA School of Medicine, Los Angeles (Drs Benson and Cummings), and the Neurology (Drs Cummings and Benson) and Geropsychiatry (Dr Tsai) Services, Brentwood (Calif) Veterans Administration Hospital.

Arch Neurol. 1982;39(10):616-620. doi:10.1001/archneur.1982.00510220014003

• The angular gyrus syndrome (posterior aphasia, alexia with agraphia, and Gerstmann's syndrome) shares many clinical features with Alzheimer's disease, and the two conditions are easily confused. Preservation of memory and topographical orientation and the specific typology of the language defects help to distinguish the angular gyrus syndrome. X-ray computed tomograms may prove misleading, but isotope metabolic studies demonstrated left posterior cortical hypometabolism in two cases.

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