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November 1982

Response of Patients With Amyotrophic Lateral Sclerosis to Testosterone Therapy: Endocrine Evaluation

Author Affiliations

From the Department of Neurology (Drs Yu and Antel) and Medicine (Dr Jones), University of Chicago.

Arch Neurol. 1982;39(11):721-722. doi:10.1001/archneur.1982.00510230047014

• Four men with amyotrophic lateral sclerosis (ALS) were treated with 200 mg of intramuscular testosterone weekly. Endocrine evaluation, using a gonadotropin-releasing hormone infusion test, indicated the expected degree of suppression of pituitary luteinizing hormone and follicle-stimulating hormone production. These data suggest that testosterone's (androgen) interaction with its receptors in the hypothalamic-pituitary axis is normal in patients with ALS.

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