[Skip to Navigation]
November 1982

Treatment of Restless Legs Syndrome With Levodopa Plus Benserazide

Author Affiliations

Department of Neurology Gülhane Military Medical Academy and Medical Faculty Etlik-Ankara, Turkey

Arch Neurol. 1982;39(11):739. doi:10.1001/archneur.1982.00510230065027

To the Editor.—  We treated five patients, three men and two women, with restless legs syndrome. Their ages ranged from 33 to 54 years, and the duration of their symptoms from two to 20 years. Their symptoms were moderate to severe in degree, and they were followed up for six to 18 months.The symptom common to all subjects was a disturbing feeling in the legs urging them to move their legs1; one also had pain. These symptoms appeared only during attempts to sleep and relaxation periods. Involuntary jerking movements of the legs, which occurred along with the preceding symptoms, made the patients uncomfortable and caused insomnia.Four subjects were given 200 mg of levodopa and 50 mg of benserazide about an hour before going to sleep. In the remaining subject, whose severe affliction had heredofamilial characteristics, the daily dosage of the drug was 500 to 750 mg. All patients