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December 1982

Endocrine Dysfunction in Temporal Lobe Epilepsy-Reply

Arch Neurol. 1982;39(12):787. doi:10.1001/archneur.1982.00510240049019

In Reply.—  Sexual and reproductive dysfunction are common in persons with temporal lobe epilepsy. It is unlikely, however, that these features are attributable solely to the psychological impact of the seizure condition or the use of antiseizure medications, as they are not common in persons with other types of seizure disorders treated with the same medications.1,2 Their occurrence appears to be related rather to the existence of seizure discharges in limbic structures of the temporal lobe.2,3 They may be improved by temporal lobectomy or antiseizure medications or during the immediate postictal state, presumably because of the control of these seizure discharges.2 The mechanism by which the discharges contribute to sexual and reproductive dysfunction, however, has not been established. The demonstration of neuroendocrine dysfunction in temporal lobe epilepsy is consistent with a hormonal pathophysiologic mechanism (Archives 1982;39:133-135). There is considerable evidence, in particular, to implicate hyperprolactinemia as a cause of