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January 1983

Bilateral Optic Neuropathy With Remission in Young Men: Variation on a Theme by Leber?

Author Affiliations

From the Departments of Ophthalmology, Anatomy, and Neurology, Boston University School of Medicine (Dr Lessell); the Department of Ophthalmology, University of Massachusetts Medical School, Boston (Dr Gise); and the Departments of Ophthalmology and Neurology, Albany (NY) Medical College (Dr Krohel).

Arch Neurol. 1983;40(1):2-6. doi:10.1001/archneur.1983.04050010022005

• Five young men had painless, progressive, bilateral loss of central vision with late optic atrophy. One had a family history of Leber's optic neuropathy. After being functionally blind for four to 21 months, spontaneous improvement began leading to remarkable recovery of vision in all patients. We propose that these are cases of Leber's optic neuropathy in which an unusual capacity for recovery may have been related to a lack of microvascular abnormalities in the fundi.