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January 1983

Baclofen: Its Effect on Seizure Frequency

Author Affiliations

From the Neurology Service, Veterans Administration Medical Center, Pittsburgh (Dr Terrence); the Department of Neurology, University of Pittsburgh School of Medicine (Dr Fromm); and the Department of Rehabilitation Medicine, Albert Einstein College of Medicine, Bronx, NY (Dr Roussan).

Arch Neurol. 1983;40(1):28-29. doi:10.1001/archneur.1983.04050010048011

• Baclofen has been reported to be epileptogenic in man, but many animal studies have demonstrated an anticonvulsant effect. In 12 patients with a history of epilepsy, baclofen was given in the conventional dosage range. In the six patients with anticonvulsant-controlled seizures, none had a seizure during baclofen therapy. In the six patients with uncontrolled epilepsy, two patients had one more seizure per month while receiving baclofen, and a third went from four seizures per month to one per month. Baclofen does not appear to have a deleterious effect in patients with epilepsy.

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