Central pontine myelinolysis (CPM), a frequently fatal disorder, is often associated with hyponatremia.1-3 To our knowledge, the first reported case of concurrent CPM and Addison's disease is described herein. The clinical dilemma of proper treatment of severe hyponatremia is exemplified by this case.
REPORT OF A CASE
A 17-year-old girl had amenorrhea 11/2 years before her admission to St Agnes Hospital, Baltimore, on Nov 16, 1980, because of a three-week history of progressive weakness, abdominal pain, anorexia, vomiting, hypotension (BP, 86/56 mm Hg), and severe electrolyte imbalance (serum sodium level, 100 mEq/L; potassium level, 6.6 mEq/L; chloride level, 68 mEq/L; carbon dioxide level, 20 mEq/L; serum urea nitrogen level, 16 mEq/L; glucose level, 78 mEq/L). She had dry skin, dry mucous membranes, and sunken eyes. Her skin was deeply tanned and she was sexually mature. Other than general weakness, results of a neurological examination were normal. Initial treatment
Kandt RS, Heldrich FJ, Moser HW. Recovery From Probable Central Pontine Myelinolysis Associated With Addison's Disease. Arch Neurol. 1983;40(2):118–119. doi:10.1001/archneur.1983.04050020080020
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: