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March 1983

Multimodality Evoked Potentials and Neurophysiological Tests in Multiple Sclerosis: Effects of Hyperthermia on Test Results

Author Affiliations

From the Biomedical Engineering Program (Mr Phillips and Dr A. R. Potvin) and the Department of English (Dr J. H. Potvin), The University of Texas at Arlington; the Neurology and Research Service, Veterans Administration Wadsworth Medical Center, Los Angeles (Drs Syndulko, Cohen, and Tourtellotte); and the Department of Neurology, School of Medicine, UCLA (Drs Cohen and Tourtellotte).

Arch Neurol. 1983;40(3):159-164. doi:10.1001/archneur.1983.04050030053010

• Data on critical frequency of photic driving (CFPD), frequency following response (FFR), and visual, somatosensory (peroneal nerve), and brain-stem auditory evoked potentials (EPs) were obtained from 20 patients who had clinically definite multiple sclerosis and ten healthy normal subjects in a controlled, balanced study under normothermic and hyperthermic (+1 °C) conditions with a test-retest interval of one week. Normal subjects' test results showed no changes during hyperthermia. Patients' EP and CFPD data correlated well with history, clinical signs, and symptoms during both normothermia and hyperthermia. The FFR test data were equivocal and not fully analyzed. Data from the four other tests showed additional patient abnormalities during hyperthermia. Multimodality testing increased the number of patient abnormalities compared with single tests, and the number increased further during hyperthermia. Test-retest reproducibility was higher during hyperthermia.

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