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March 1983

Naloxone Dosage

Author Affiliations

836 W Wellington St Chicago, IL 60657

Arch Neurol. 1983;40(3):189. doi:10.1001/archneur.1983.04050030083019

To the Editor.  —I was much interested in the report by Trabucchi et al (Arch Neurol 1982;39:120-121) on the effect of naloxone hydrochloride on the "on-off" syndrome in patients receiving levodopa for parkinsonism. Naloxone is currently being proposed as treatment for postangiographic and post-operative hemiparesis in some neurosurgical patients, but in small doses such as those used by anesthesiologists (ie, 0.4 mg). Trabucchi et al stated that they gave 8 mg in 20 mL of saline solution, but provided no detail as to whether it was given as a slow intravenous (IV) drip or a single injection over a few minutes, and whether it was given once a day only for the three successive days of the "active phase" of treatment. It is acknowledged that naloxone has virtually no pharmacologic action in persons who have not been given narcotics. Howerer, in this apparently large dose, it is necessary