[Skip to Navigation]
March 1983

Naloxone Dosage-Reply

Author Affiliations

Department of Pharmacology
Department of Neurology University of Milan Milan, Italy

Arch Neurol. 1983;40(3):189. doi:10.1001/archneur.1983.04050030083020

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


In Reply.  —We have used naloxone hydrochloride experimentally in patients with parkinsonism treated with levodopa for a long period. The drug was given in a single IV injection over three to four minutes, once daily for three successive days. It exerts its effects on central neuronal mechanisms previously perturbed by pharmacologic manipulations, as in persons treated with narcotics or, as in our trial, with levodopa.In our experience, significant results were obtained only after administering relatively high doses of naloxone hydrochloride (8 mg), and we reported the side effects observed. In fact, naloxone administration at this dosage did not cause any side effects in normal subjects, as previously indicated by other authors,1 who also used higher dosages of the drug.

First Page Preview View Large
First page PDF preview
First page PDF preview
Add or change institution