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Article
April 1983

A Family With Histologically Confirmed Alzheimer's Disease

Author Affiliations

From the Laboratories of Clinical Science (Ms Nee and Drs Polinsky and Ebert) and Psychology and Psychopathology (Dr Weingartner and Ms Smallberg), National Institute of Mental Health, and Clinical Neurogenetic Studies, National Institute of Neurological and Communicative Diseases and Stroke (Dr Eldridge), Bethesda, Md.

Arch Neurol. 1983;40(4):203-208. doi:10.1001/archneur.1983.04050040033004
Abstract

• A Canadian family comprising 51 members affected with Alzheimer's disease was evaluated clinically, histologically, and genetically. Ancestors were traced through eight generations, and 51 members were examined at the National Institute of Mental Health, Bethesda, Md. The pedigree is consistent with autosomal dominant inheritance. The effect of interrelatedness among some parents of affected individuals is unknown. In contrast to other studies, there was not an increased incidence of Down's syndrome, hematologic malignancy, or preponderance of affected females.

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