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April 1983

CSF Polyamines in Childhood

Author Affiliations

From the Department of Neurosurgery, Children's Hospital of Pittsburgh (Dr Albright); Brain Tumor Research Center, Department of Neurological Sciences (Dr Marton and Mr Lubich) and the Department of Laboratory Medicine (Dr Marton), University of California School of Medicine, San Francisco; and the Department of Neurosurgery, West Penn Hospital, Pittsburgh (Dr Reigel).

Arch Neurol. 1983;40(4):237-240. doi:10.1001/archneur.1983.04050040067011

• Specimens of CSF from 76 children without neurologic disease and from 191 children with neurosurgical conditions were assayed for polyamine content. Putrescine and spermidine concentrations decreased with age. In children with intracranial tumors, polyamine concentrations in lumbar CSF were comparable with those in ventricular CSF. Putrescine level was significantly increased in children with medulloblastomas. Spermidine level was increased in children with medulloblastomas, glioblastomas, and astrocytomas. Concentrations of putrescine and spermidine were significantly increased in infants with myelomeningocele and hydrocephalus. Spermidine concentrations were significantly increased in older children with myelomeningocele, encephalocele, and hydrocephalus. Poylamines thus seem to be increased by rapid cell proliferation and by disorders affecting myelination. Since putrescine and spermidine concentrations may be of use in monitoring tumor progression, the effects of childhood growth and of hydrocephalus must be considered for children whose brain tumors are associated with hydrocephalus.

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