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April 1983

Paroxysmal Unilateral Hyperhidrosis and Malignant Mesothelioma

Author Affiliations

From the Departments of Medicine (Drs Pleet and Neilan) and Neurology (Dr Mandel), Temple University Health Sciences Center and School of Medicine, Philadelphia.

Arch Neurol. 1983;40(4):256. doi:10.1001/archneur.1983.04050040086020

This report describes a patient with localized unilateral hyperhidrosis secondary to malignant mesothelioma and discusses the pathophysiology involved.

REPORT OF A CASE  A 35-year-old man experienced severe pleuritic-type pain in the right anterior portion of the chest for six months before admission to the hospital. He also had anorexia, malaise, and a 9-kg weight loss. One month before admission he suffered profuse sweating of his face and right upper torso, including his right arm, that was unrelated to eating, hunger, sleep, urination, or defecation. The sweating became so severe that the patient slept with towels wrapped around his arm and changed his pajamas several times during the day.He had not had tuberculosis, diabetes, rheumatic fever, hypertension, or cardiac distress. He had worked in Italy pouring concrete, but denied exposure to asbestos or excessive dust. He did not smoke or drink alcohol.On admission to Temple University Hospital, Philadelphia, he

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