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May 1983

Computed Tomography in Acute Cerebral Multiple Sclerosis: A Report of Two Cases

Author Affiliations

From the Department of Neurology, St Annadal Hospital, Medical Faculty of the Rijksuniversiteit Limburg, Maastricht, the Netherlands (Dr Lodder and Dr van der Lugt), the TNO Research Unit of Neurophysiology, Westeinde Hospital, The Hague (Dr de Weerd), and the Department of Neurology, Vrije Universiteit, Amsterdam (Dr Koetsier).

Arch Neurol. 1983;40(5):320-322. doi:10.1001/archneur.1983.04050050088015

• In two cases of acute cerebral multiple sclerosis, computed tomographic (CT) scans with contrast disclosed several enhanced foci, mainly situated in the periventricular white matter and, in one patient, in the cerebellum. Administration of dexamethasone sodium phosphate in one patient and prednisone with cyclophosphamide in the other was followed by considerable clinical improvement. Successive CT scans with contrast enhancement showed a close correlation between improvement of symptoms and the subsidence of contrast-enhanced foci during treatment. Perhaps clinical improvement reflected restoration of the impaired blood-brain barrier.