• In two cases of acute cerebral multiple sclerosis, computed tomographic (CT) scans with contrast disclosed several enhanced foci, mainly situated in the periventricular white matter and, in one patient, in the cerebellum. Administration of dexamethasone sodium phosphate in one patient and prednisone with cyclophosphamide in the other was followed by considerable clinical improvement. Successive CT scans with contrast enhancement showed a close correlation between improvement of symptoms and the subsidence of contrast-enhanced foci during treatment. Perhaps clinical improvement reflected restoration of the impaired blood-brain barrier.
Lodder J, de Weerd AW, Koetsier JC, van der Lugt PJM. Computed Tomography in Acute Cerebral Multiple Sclerosis: A Report of Two Cases. Arch Neurol. 1983;40(5):320–322. doi:10.1001/archneur.1983.04050050088015
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