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July 1983

Multiple Sclerosis Susceptibility: Interaction Between Sex and HLA

Author Affiliations

From the Departments of Psychiatry and Pediatrics and the Division of Genetics, University of Rochester (NY) School of Medicine and Dentistry.

Arch Neurol. 1983;40(7):399-401. doi:10.1001/archneur.1983.04050070029004

• The sex of patients with multiple sclerosis (MS) in relation to the sex, number, and relationship of affected relatives indicates an interaction between sex and autosomal genes in determining susceptibility to MS in some persons. This conclusion is confirmed by the observation that the proportion of laterally-related affected female pairs (siblings or cousins) who share the maximum possible number of HLA haplotypes is greater than that proportion in corresponding unlike-sex pairs.

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