• After four months of excessive nitrous oxide (N2O) exposure, a dentist had myeloneuropathy with spastic paraparesis, Lhermitte's sign, sensory shading, loss of position and vibration sense, ataxia, and impotence. Macrocytosis, hypersegmented neutrophils, and a reduced vitamin B12 level were associated with normal findings on gastric analysis and Schilling test. Complete hematologic and neurologic recovery followed N2O avoidance and vitamin therapy for six months.
Blanco G, Peters HA. Myeloneuropathy and Macrocytosis Associated With Nitrous Oxide Abuse. Arch Neurol. 1983;40(7):416–418. doi:10.1001/archneur.1983.04050070046009
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