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July 1983

Ethylene Oxide—Induced Polyneuropathy: A Clinical and Electrophysiologic Study

Author Affiliations

From the Medical Service (Dr Finelli) and Physical Medicine and Rehabilitation Service (Dr Granger), Pawtucket (RI) Memorial Hospital, the Neurology Service, Rhode Island Hospital, (Providence) (Dr Morgan), the Neurology Service, Providence (RI) Veterans Administration Medical Center (Drs Finelli and Yaar), and the Division of Biological and Medical Services, Brown University, Providence (Drs Finelli, Morgan, and Granger).

Arch Neurol. 1983;40(7):419-421. doi:10.1001/archneur.1983.04050070049010

• Occupational exposure to ethylene oxide (ETO) was manifested as a subacute polyneuropathy, with bilateral footdrop and denervation potentials on electromyography as the principal abnormalities in three young adults whom we examined. To our knowledge, this is the second report of neurotoxic effects caused by long-term ETO exposure in humans and brings the number of patients described with symptomatic polyneuropathy to five.

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