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August 1983

Midline Spikes: EEG and Clinical Features

Author Affiliations

From the Department of Neurology, University of New Mexico School of Medicine, and the Neurology Service, Veterans Administration Medical Center, Albuquerque.

Arch Neurol. 1983;40(8):473-476. doi:10.1001/archneur.1983.04210070013005

• Clinical features of 40 patients with midline spikes on EEG were compared with those of age- and sex-matched controls. Seizure incidence was significantly greater in the study group than in the controls (85% v 45%). Tonic-clonic seizures were the most frequent type. Eighteen patients from the study group had additional focal or generalized epileptiform abnormalities. This subgroup had a significantly greater incidence of seizures than patients with only midline spikes (100% v 73%). Midline spikes are more common in children and markedly activated with sleep. They must be distinguished from normal sleep transients.

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