[Skip to Content]
[Skip to Content Landing]
August 1983

Anticonvulsant Activity of Clomiphene

Author Affiliations

Department of Neurology University of Virginia School of Medicine Charlottesville, VA 22908

Arch Neurol. 1983;40(8):525. doi:10.1001/archneur.1983.04210070065018

To the Editor.  —We eagerly respond to the suggestion by Check et al (Archives 1982;39:784) that clomiphene may have anticonvulsant properties.

Report of a Case.  —In June 1979, a 16-year-old girl was examined at the Epilepsy Unit of the University of Virginia Medical Center, Charlottesville, because of persistent seizures and amenorrhea. Refractory generalized convulsions had begun at 2 years and absence seizures at 4 years of age. Over the years, therapy with at least 12 anticonvulsant medications and a ketogenic diet had achieved only minimal seizure control.At 14 years of age, taking phenobarbital, ethosuximide, and carbamazepine, she had almost continuous absence seizures when awake and frequent generalized convulsions when asleep. During a 12-hour video-telemetry recording, she experienced more than 900 absence seizures. A routine EEG revealed generalized, atypical, 1.5- to 2-Hz spike and wave complexes. The patient's impaired intellect, her mixed and uncontrolled seizures, and her EEG pattern were