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September 1983

CNS Lesions in Neonatal Isoimmune Thrombocytopenia

Arch Neurol. 1983;40(9):552-554. doi:10.1001/archneur.1983.04050080052009

• We treated two siblings with classic neonatal isoimmune thrombocytopenia and porencephalic cysts in whom the CNS lesions occurred in a vascular distribution, for which there is no clear explanation. Whether the CNS vasculature is injured by the immune process at certain susceptible sites in larger vessels or whether there is a thrombotic process occurring at sites of vascular injury is speculative. This observation suggests that vascular factors are involved in the development of CNS lesions in this condition.