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September 1983

CNS Lesions in Neonatal Isoimmune Thrombocytopenia

Author Affiliations

From the Departments of Pediatrics and Neurology (Drs Naidu and Caserta), Hematology (Dr Messmore), and Neuroradiology (Dr Fine), Loyola University Medical Center, Stritch School of Medicine, Maywood, Ill.

Arch Neurol. 1983;40(9):552-554. doi:10.1001/archneur.1983.04050080052009

• We treated two siblings with classic neonatal isoimmune thrombocytopenia and porencephalic cysts in whom the CNS lesions occurred in a vascular distribution, for which there is no clear explanation. Whether the CNS vasculature is injured by the immune process at certain susceptible sites in larger vessels or whether there is a thrombotic process occurring at sites of vascular injury is speculative. This observation suggests that vascular factors are involved in the development of CNS lesions in this condition.

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