Improving the lot of patients with multiple sclerosis (MS) is an important priority. There have been considerable refinements in the design and planning of clinical trials, and the need for uniform criteria for diagnosis and assessment is self-evident. Some sense of satisfaction for what we have achieved is justified. However, lest we be tempted to feel too pleased with ourselves, it might be salutary to look back over our predecessors' attempts to adopt a rational approach to the disease. This article reviews the regimens advised by leading practitioners between 1822 and 1950. If I emphasize the English School, it is because I recently had the good fortune to hear a firsthand account of therapeutic practice in the 1920s and 1930s from my former teachers, MacDonald Critchley and Denis Brinton.
To my knowledge, the earliest detailed account of the treatment of what was undoubtedly MS appears in a diary
McDonald WI. Attitudes to the Treatment of Multiple Sclerosis. Arch Neurol. 1983;40(11):667–670. doi:10.1001/archneur.1983.04050100007002
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