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November 1983

The Fluorodeoxyglucose 18F Scan in Alzheimer's Disease and Multi-infarct Dementia

Author Affiliations

From the Department of Neurology (Dr Benson), Division of Nuclear Medicine (Drs Kuhl and Hawkins), and Divisions of Nuclear Medicine and Biophysics (Dr Phelps), UCLA School of Medicine, and the Departments of Neurology (Drs Benson and Cummings) and Psychiatry (Dr Tsai), Brentwood Veterans Administration Medical Center, Los Angeles.

Arch Neurol. 1983;40(12):711-714. doi:10.1001/archneur.1983.04050110029003

• Patients with Alzheimer's disease and multi-infarct dementia were studied with scans using fluorodeoxyglucose tagged with fluorine 18. The rates of glucose metabolism were calculated. Patients with Alzheimer's dementia showed decreased metabolism in all areas of the brain but with preferential sparing of the primary motor and sensory cortex. Patients with multi-infarct dementia also had global reductions in glucose metabolic rates when compared with normal control subjects, but the areas of hypometabolism were focal and asymmetric.

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