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November 1983

Prevalence of Psychosis in Temporal Lobe Epilepsy

Author Affiliations

National Institute of Mental Health St Elizabeths Hospital WAW Bldg 536 Washington, DC 20032

Arch Neurol. 1983;40(12):773. doi:10.1001/archneur.1983.04050110091023

To the Editor.  —The study by Sherwin et al concerning the occurrence of psychosis in TLE appears to be a rigorous evaluation of the effects of laterality of the focus on the occurrence of psychosis in a population with medically intractable epilepsies. However, several of their conclusions are at variance with the results of studies of some larger, less highly selected populations. For example, Kristensen and Sindrup,1,2 in a study of nearly 200 patients with TLE, half with schizophreniform psychosis and half without, were unable to show any preferential laterality of focus. This was also the case for Jensen and Larsen's3 large series of 74 patients who underwent temporal lobectomies for TLE, Taylor's 100 cases,4 and 29 patients with epilepsy and psychosis recently reviewed by Parnas and Korsgaard.5 Indeed, recently Levine and Finklestein6 reported eight cases of stroke, epilepsy, and psychosis uniquely associated with right-sided (temporoparietal) lesions. In