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Clinical Notes
December 1983

Tuberous Sclerosis With Intracranial Aneurysm

Author Affiliations

From the Department of Medicine, Division of Neurology, University of Texas Health Science Center, San Antonio.

Arch Neurol. 1983;40(13):826-827. doi:10.1001/archneur.1983.04050120076015

The classic renal lesion in tuberous sclerosis (TS) is angiomyolipoma with aneurysmal formation in the interlobar arteries. Aneurysms of cerebral vessels in TS have been found only twice.1,2 We report a third case that suggests that renal and intracranial aneurysms in TS may represent a common defect.

REPORT OF A CASE  A 17-year-old girl had major motor seizures for seven years. At age 12 years, she had an IQ of 80. A maternal aunt also had seizures. New symptoms of déjà vu followed by right focal motor seizures prompted hospitalization. An adenoma sebaceum, pitting of her teeth, and one shagreen patch were noted. Neurologic examination showed a visual acuity of 20/20 OD, 20/30 OS, a Marcus Gunn's pupillary sign OS with optic pallor, and a left inferior altitudinal defect. A computed tomographic scan revealed periventricular calcifications and an enhancing lesion in the left parasellar region (Fig 1). Cerebral angiograms

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