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Letters to the Editor
December 1983

Cataplexy Relieved by Tiapride

Author Affiliations

Medizinische Einrichtungen Universität Düsseldorf Neurologische Klinik Moorenstr. 5 4000 Düsseldorf1 1 West Germany

Arch Neurol. 1983;40(13):828. doi:10.1001/archneur.1983.04050120078016

Letters to the editor should be submitted as an original and two duplicates. They should be typewritten double-spaced on plain bond paper; they will be subject to editing. A copyright transmittal letter signed by all authors must accompany this (see "Instructions for Authors").

To the Editor.  —Cataplexy, which usually occurs as part of a narcoleptic syndrome, is characterized by a sudden loss of muscle tone in an alert patient, frequently triggered by emotional upset or physical exercise. It is thought to be closely related to atony in paradoxical sleep.1 Various pharmacologic treatments for narcolepsy and cataplexy have been reported in recent years.2There is general agreement that excessive daytime sleepiness and irresistible sleep attacks are best relieved by amphetamine derivatives such as methylphenidate hydrochloride or pemoline.3 In contrast, cataplexy and sleep paralysis are better controlled by tricyclic antidepressant agents, especially clomipramine hydrochloride4 and protryptiline hydrochloride.5

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