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Letters to the Editor
December 1983

Neuropathologic Data in Alzheimer's Disease

Author Affiliations

7221 Pyle Rd Bethesda, MD 20817

Arch Neurol. 1983;40(13):830. doi:10.1001/archneur.1983.04050120080020

To the Editor.  —Alzheimer's disease (AD) is a cliniconeuropathologic process. Therefore, any article that does not include specific neuropathologic data for each case can hardly be considered a contribution to the study of AD. The article by Seltzer and Sherwin (Archives 1983;40:143-146) is a good example of this deficiency. Their investigation is completely invalidated by the total lack of neuropathologic confirmation of AD.In the introductory paragraph of the article, the authors stated that the duality of the disorder, the separation of AD into senile and presenile types, is losing favor. We have not seen much evidence of this trend in the voluminous recent literature where, by far, the largest number of articles still refer to AD and senile dementia of the Alzheimer type. While there may be some variations in clinical features, the progressive deterioration of the conditions of patients, as observed by the attending physician, and the widespread

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