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January 1984

Effect of Clomiphene on EEG Activity

Author Affiliations

Haifa City Medical Center Haifa, Israel

Arch Neurol. 1984;41(1):14. doi:10.1001/archneur.1984.04050130016006

To the Editor.  —We read with interest the article by Check and colleagues (Archives 1982;39:784) about the possible anticonvulsant action of clomiphene citrate. Based on experimental evidence suggesting that estrogens increase the electrical excitability of the brain, the authors assumed that the anticonvulsant action of clomiphene, an antiestrogen agent, may be associated with suppression of brain excitability.We published a study in 1969, showing the beneficial effect of clomiphene on abnormal EEG activity.1 Of 85 women treated for amenorrhea and anovular sterility, 48 (56.5%) had abnormal EEGs before treatment. In 26 patients, the abnormality consisted of general irregularity and theta wave activity, 14 showed slow (delta) wave activity, and eight showed general bursts of sharp slow waves and/or spike discharges.Clomiphene treatment normalized the EEG activity in 26 (54%) of the patients. This normalization was accompanied by a high percentage of ovulation and pregnancy, indicating the hypothalamus as a

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