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January 1984

Dissociation of Glucose and Potassium Arterial-Venous Differences Across the Forearm by Acetazolamide: A Possible Relationship to Acetazolamide's Beneficial Effect in Hypokalemic Periodic Paralysis

Author Affiliations

From the Department of Neurology, West Virginia University School of Medicine, Morgantown (Dr Riggs), and the Departments of Neurology (Drs Griggs and Moxley), Medicine (Dr Griggs), and Pediatrics (Dr Moxley), University of Rochester (NY) School of Medicine and Dentistry.

Arch Neurol. 1984;41(1):35-38. doi:10.1001/archneur.1984.04050130041019

• We studied the effect of acetazolamide on arterial-venous (A-V) glucose and potassium differences across the forearm following oral glucose loading in eight normal subjects. Administration of acetazolamide for 72 hours prior to glucose loading resulted in increased A-V glucose differences and decreased A-V potassium differences. Acetazolamide may, therefore, increase glucose uptake across muscle while decreasing potassium uptake following glucose ingestion. This glucose-potassium dissociation observed in normal subjects may relate to acetazolamide's beneficial effect in hypokalemic periodic paralysis.