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January 1984

Dissociation of Glucose and Potassium Arterial-Venous Differences Across the Forearm by Acetazolamide: A Possible Relationship to Acetazolamide's Beneficial Effect in Hypokalemic Periodic Paralysis

Arch Neurol. 1984;41(1):35-38. doi:10.1001/archneur.1984.04050130041019

• We studied the effect of acetazolamide on arterial-venous (A-V) glucose and potassium differences across the forearm following oral glucose loading in eight normal subjects. Administration of acetazolamide for 72 hours prior to glucose loading resulted in increased A-V glucose differences and decreased A-V potassium differences. Acetazolamide may, therefore, increase glucose uptake across muscle while decreasing potassium uptake following glucose ingestion. This glucose-potassium dissociation observed in normal subjects may relate to acetazolamide's beneficial effect in hypokalemic periodic paralysis.