• Five lectins were used as fluorescence microscopic markers for sugar residues in skeletal muscle. Biopsy specimens were taken from patients with X-linked muscular dystrophy (Duchenne's and Becker's), patients with other neuromuscular diseases, and normal controls. In both the controls and the pathologic samples, concanavalin A gave a bright fluorescence of the myofiber surface, whereas soybean agglutinin and Dolichos biflorus agglutinin fluorescence was negative. Peanut agglutinin and wheat germ agglutinin were more avidly bound to the sarcolemma and/or endomysial connective tissue in the patients with X-linked muscular dystrophy than in the controls or the patients with other conditions. The altered saccharide pattern may reflect either a myofiber membrane change or a specific mesenchymal reaction in the dystrophic muscle.
Paljärvi L, Karjalainen K, Kalimo H. Altered Muscle Saccharide Pattern in X-Linked Muscular Dystrophy. Arch Neurol. 1984;41(1):39–42. doi:10.1001/archneur.1984.04050130045020
Neurology in JAMA: Read the Latest
Customize your JAMA Network experience by selecting one or more topics from the list below.