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February 1984

Effect of Baclofen on Seizure Frequency

Author Affiliations

Freie Universität Berlin Universitätsklinikum Steglitz Neurochirurg/Neurolog Klinik u Polikinik Abteilung für Neurologie Hindenburgdamm 30 D 1000 Berlin 45, West Germany

Arch Neurol. 1984;41(2):134. doi:10.1001/archneur.1984.04050140032005

To the Editor  —The conclusion of Terrence et al1 that baclofen in usual therapeutic doses does not seem to be epileptogenic may be based on chance observations. The epilepsy of their six controlled patients usually had a good spontaneous prognosis and was not suitable for pharmacologic treatment. One of these six patients showed a major change in seizure frequency concurrent with baclofen administration, yet previous monthly variation of seizure frequency was not described, making interpretation difficult. Furthermore, serum concentrations of the drugs were not available.The authors' data argued neither against an epileptogenic nor for an anticonvulsant action of baclofen. It may be remembered, however, that several presumably or definitely seizure-free patients were described who had epileptic phenomena while receiving baclofen. One patient had a generalized tonic-clonic seizure,2 and two had myoclonia in the recovery phase after baclofen overdose induced a coma.3,4 An epileptic stupor with continuous

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