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February 1984

Metoprolol Compared With Propranolol in the Treatment of Essential Tremor

Author Affiliations

From the Department of Neurology, Loyola University Medical School, Maywood, Ill (Dr Koller), and the Department of Neurology, University of Illinois College of Medicine, Chicago (Dr Biary).

Arch Neurol. 1984;41(2):171-172. doi:10.1001/archneur.1984.04050140069026

• We analyzed effects of metoprolol tartrate and propranolol hydrochloride on 23 patients with essential tremor. Tremor was assessed by patient self-evaluation, clinical scoring, and tremorgrams. Ten of 20 patients had tremor reduction with propranolol. Metoprolol decreased tremor in 13 of 23 patients, including three patients with asthma in whom propranolol had caused respiratory distress. Adverse reactions were infrequent. Individual patients either responded to both propranolol and metoprolol or to neither drug. Patient age, duration of tremor, tremor frequency, family history, or response to intravenous ethyl alcohol did not distinguish responders from nonresponders.

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