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March 1984

Increased Intracranial Pressure in Adrenoleukodystrophy

Author Affiliations

From the Departments of Neurology (Drs Chaves-Carballo and Frank), Pediatrics (Drs Chaves-Carballo, Frank, and Chrenka), and Pathology (Dr Chrenka), Eastern Virginia Medical School, and Children's Hospital of the King's Daughters, Norfolk, Va.

Arch Neurol. 1984;41(3):339-340. doi:10.1001/archneur.1984.04050150121031

• Increased intracranial pressure developed as a terminal event in a 5-year-old boy with adrenoleukodystrophy. The CSF protein concentration was 420 mg/dl. Computed tomography showed extensive areas of decreased density in the posterior cerebral white matter. At autopsy, brain weight exceeded the expected value by 20%, and white matter water content was 87.6% (expected value, 72.5%). In rare instances, brain edema may contribute to the development of increased intracranial pressure in adrenoleukodystrophy.

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