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May 1984

Quantitative Axon Terminal and End-plate Morphology in Amyotrophic Lateral Sclerosis

Author Affiliations

From the ALS and Neuromuscular Research Center, and the Medical Research Institute of San Francisco, Pacific Medical Center (Ms Bjornskov and Dr Norris), and the Department of Biology, San Francisco State University (Dr Mower-Kuby).

Arch Neurol. 1984;41(5):527-530. doi:10.1001/archneur.1984.04050170073021

• An axon-end-plate double stain yielded more synaptic detail than the older methylene blue stain of the muscle biopsy specimen. Application of the double stain to amyotrophic lateral sclerosis confirmed earlier and well-known findings of denervation, abnormal end-plates, and axonal sprouting. Little new data emerged, however, and the sprouting index seemed to mislead. As in several previous investigations, muscle from normal human subjects showed evidence for at least past if not current denervation, substantiating the need for continued rigorous controls in such studies.

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