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May 1984

Abetalipoproteinemia and Metastatic Spinal Cord Glioblastoma

Author Affiliations

From the Experimental Therapeutics (Dr Newman) and Surgical Neurology (Dr Oldfield) Branches, National Institute of Neurological and Communicative Disorders and Stroke, the Molecular Disease Branch, National Heart, Lung, and Blood Institute (Dr Schaefer), and the Laboratory of Clinical Pathology, National Cancer Institute (Dr Thomas), National Institutes of Health, Bethesda, Md.

Arch Neurol. 1984;41(5):554-556. doi:10.1001/archneur.1984.04050170104026

• Abetalipoproteinemia (ABL [Bassen-Kornzweig syndrome]) is characterized by marked hypolipidemia with absence of low-density lipoproteins, fat-soluble vitamin deficiency, spinocerebellar ataxia, and retinitis pigmentosa. Our patient had ABL, severe neurologic disease, and spinal cord malignancy, as well as disseminated CNS and extraneural metastases. It is possible that patients with this disorder and long-standing fat-soluble vitamin deficiency may have increased risk for CNS malignancy.

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