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June 1984

Staphylococcal CNS Infections Treated With Vancomycin and Rifampin

Author Affiliations

From The Children's Mercy Hospital and the Department of Pediatrics, University of Missouri-Kansas City, School of Medicine.

Arch Neurol. 1984;41(6):637-639. doi:10.1001/archneur.1984.04210080045011

• Three children had staphylococcal infections of the CNS. In two cases the organisms were resistant to methicillin sodium. Each case was treated with a combination of vancomycin hydrochloride and rifampin; in one instance vancomycin alone had been unsuccessful. The addition of rifampin resulted in prompt clinical and bacteriologic resolution. Satisfactory levels of rifampin were achieved by administering the drug either orally or intravenously, and in one patient oral administration of rifampin produced assayed levels in subdural pus many times that required for minimal bactericidal activity. Combination therapy with vancomycin and rifampin is recommended for staphylococcal infections of the CNS.

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