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July 1984

Interaction Between Sex and HLA in a Population Study

Author Affiliations

Multiple Sclerosis Clinic Hôpital Notre-Dame Montreal, Quebec Canada H2L 4K8

Arch Neurol. 1984;41(7):703-704. doi:10.1001/archneur.1984.04050180025005

To the Editor.  —In his recent article, Weitkamp1 suggests an interaction between sex genes and autosomal genes in determining susceptibility to multiple sclerosis (MS) in some but not all persons. His calculations were based on families with more than one person afflicted with MS. We would like to contribute further to this aspect.

Subjects and Methods.  —We have studied the distribution of HLA according to sex in nonfamilial cases of MS. This was done in two groups of patients, one from the MS clinic in London, Ontario (data supplied by G. C. Ebers, MD, written communication, July 1982), one from the two MS clinics in Montreal (HLA typing performed and supplied by G. Lamoureux, MD, written communication, July 1981). Controls were chosen from among normal persons from the same area. A total of 328 patients with MS (nonrelated), 208 women and 120 men, and 467 controls, 230 women and

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