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July 1984

Communicating Hydrocephalus and Lysosomal Inclusions in Mannosidosis

Author Affiliations

From the Neurology Service, Massachusetts General Hospital, Boston, and the Eunice Kennedy Shriver Center, Waltham, Mass. Dr Halperin is now with the Health Sciences Center, State University of New York (SUNY) at Stony Brook, and Dr Lott is now with the University of California Medical Center at Irvine.

Arch Neurol. 1984;41(7):777-779. doi:10.1001/archneur.1984.04050180099027

• A 32-year-old man with mannosidosis had a gait disorder develop that was associated with communicating hydrocephalus. The gait disorder improved with ventriculoperitoneal shunting, but proximal muscle weakness remained. Biopsy specimens of muscle and nerve disclosed typical lysosomal inclusions in both tissues, as well as selective loss of unmyelinated axons.

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