• A 32-year-old man with mannosidosis had a gait disorder develop that was associated with communicating hydrocephalus. The gait disorder improved with ventriculoperitoneal shunting, but proximal muscle weakness remained. Biopsy specimens of muscle and nerve disclosed typical lysosomal inclusions in both tissues, as well as selective loss of unmyelinated axons.
Halperin JJ, Landis DMD, Weinstein LA, Lott IT, Kolodny EH. Communicating Hydrocephalus and Lysosomal Inclusions in Mannosidosis. Arch Neurol. 1984;41(7):777–779. doi:10.1001/archneur.1984.04050180099027
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.