[Skip to Content]
[Skip to Content Landing]
July 1984

Communicating Hydrocephalus and Lysosomal Inclusions in Mannosidosis

Arch Neurol. 1984;41(7):777-779. doi:10.1001/archneur.1984.04050180099027

• A 32-year-old man with mannosidosis had a gait disorder develop that was associated with communicating hydrocephalus. The gait disorder improved with ventriculoperitoneal shunting, but proximal muscle weakness remained. Biopsy specimens of muscle and nerve disclosed typical lysosomal inclusions in both tissues, as well as selective loss of unmyelinated axons.